Naturally occurring circular permutations in proteins

Naturally occurring circular permutations in proteins.

A pair of proteins is defined to be related by a circular permutation if the N-terminal region of one protein has significant sequence similarity to the C-terminal of the other and vice versa. To detect pairs of proteins that might be related by circular permutation, we implemented a procedure based on a combination of a fast screening algorithm that we had designed and manual verification of c...

Structures of naturally occurring circular proteins from bacteria.

Bacteria produce a wide variety of both proteinaceous and nonproteinaceous molecules for defense, mediation of microbial competitions, and signaling purposes. Of the proteinbased molecules, there are examples of large folded polypeptides that are translated conventionally from genes as well as smaller peptides that are assembled nonribosomally by peptide synthetases (41). The latter often conta...

Naturally occurring ehrlichiosis in Egyptian dogs

Canine ehrlichiosis has emerged as one of the most clinically important tick-borne diseases affecting dogs. Eighty-five naturally infected dogs have been investigated, the most consistent clinical signs recorded were fever, emaciation and lymphoadenopathy, anemia, monocytosis, thrompocytopenia, hypoalbuminemia, elevation in liver enzymes and total bilirubin were the most remarkable changes asso...

A simple algorithm for detecting circular permutations in proteins

MOTIVATION Circular permutation of a protein is a genetic operation in which part of the C-terminal of the protein is moved to its N-terminal. Recently, it has been shown that proteins that undergo engineered circular permutations generally maintain their three dimensional structure and biological function. This observation raises the possibility that circular permutation has occurred in Nature...

Coinfection Associated with Naturally Occurring Cryptosporidiosis in Broilers